Anthocyanins of Hierbamora (Solanum nigrescens): Revealing their Nutraceutical Potential for Controlling Hypertriglyceridemia and Helicobacter pylori Viability

Artículo

Te invitamos a leer el artículo "Anthocyanins of Hierbamora (Solanum nigrescens): Revealing their Nutraceutical Potential for Controlling Hypertriglyceridemia and Helicobacter pylori Viability"  publicado en Chemistry & Biodiversity, en el que colaboró el Dr. Edmundo Lozoya Gloria de la Unidad Irapuato.

Autores:
Yesenia Pacheco Hernández, Edmundo Lozoya Gloria, Ramiro Cruz Durán, and Nemesio Villa Ruano

Resumen:
We present the inhibitory properties of the Solanum nigrescens anthocyanin fraction (SNAF) and its major constituents on alpha-glucosidase (AG), pancreatic lipase (PL), HMG-CoA reductase, and ornithine  decarboxylase (ODC). The effect of SNAF was simultaneously evaluated in ICR male mice exposed to triglyceride charge test (TCT). HPLC-MS profiling revealed the presence cyanidin-3-O-rutinoside-5-glucoside (CRG), delphinidin-3-(p-coumaroyl)-rutinoside-5-glucoside (DCRG), and petunidin-3-(cis-p-coumaroyl)-rutinoside-5-glucoside (PCRG) as major constituents of the fraction. SNAF, CRG, and specially PCRG, induced strong non-competitive inhibition on PL (IC50, 33–86 μgmL 1). The results of TCT confirmed their capacity to ameliorate (p <0.001) hypertriglyceridemia during  postprandial and interdigestive stages. SNAF, CRG, DCRG, and PCRG caused negligible growth inhibition (MIC>600 μgmL 1 ) on beneficial bacteria whereas SNAF and DCRG exerted inhibitory ctivity on Helicobacter pylori ATCC 53504 (MIC,187-64 μgmL 1 ). Additional exploration revealed that SNAF and DCRG produced noncompetitive activity on H. pylori urease, which facilitates bacterial growth under acidic conditio.