Monica Lamas - Epigenetic mechanisms of non-retinal components of the aging eye and novel therapeutic strategies

4 de octubre del 2023

Invitamos a leer el artículo: "Epigenetic mechanisms of non-retinal components of the aging eye and novel therapeutic strategies", realizado por la Dra. Monica Lamas, Investigadora de Cinvestav Sede Sur

Autores: Monica Lamas

Abstract: The eye is a complex organ composed of various cell types, each serving a unique purpose. However, aging brings about structural and functional changes in these cells, leading to discomfort and potential pathology. Alterations in gene expression, influenced by aging and environmental factors, significantly affect cell structure and function. Epigenetics, a field focused on understanding the correlation between changes in gene expression, cell function, and environmental factors, plays a crucial role in unraveling the molecular events responsible for age-related eye changes. This prompts the possibility of developing epigenetic strategies to intervene in these changes or reinstate proper molecular activities. Indeed, research has demonstrated that epigenetic modifications, including DNA methylation, histone modification, and non-coding RNAs, are closely associated with age-related alterations in gene expression and cell function. This review aims to compile and synthesize the most recent body of evidence supporting the role of epigenetics in age-related alterations observed in various components of the eye. Specifically, it focuses on the impact of epigenetic changes in the ocular surface, tear film, aqueous humor, vitreous humor, and lens. Furthermore, it highlights the significant advancements that have been made in the field of epigenetic-based experimental therapies, specifically focusing on their potential for treating pathological conditions in the aging eye.

Keywords:  Eye Aging DNA methylation Histone modification Non-coding RNAs