Synthesis of New Isoindolines Derived from L-Α-Amino Acids and their Selectivity on Cancer Cell Lines

 

Autores. Teresa Mancilla Percino, Maricarmen Hernández Rodríguez, Elvia Mera Jiménez

Revista: Journal of Organometallic Chemistry

https://doi.org/10.1002/slct.202304299

Resumen: Isoindolines are essential from the point of view of synthesis and their biological properties, so this work is focused on the synthesis of new isoindolines derived from the following L-α-amino acids, aspartic acid (1), arginine (2), glutamic acid (3-5), serine (6), and lysine (7). All compounds were characterized by 1H and 13C NMR, infrared, and high-resolution mass spectrometry. In addition, the synthesized compounds were screened to investigate their antiproliferative activities against five human cancer cell lines, A549, U373, MDA-MB-231, MCF-7, and HeLa, as well as on primary cell culture healthy, MGC, EC, and Vero cells lines. All tested compounds exhibited activity against cancer cell lines at mM concentrations. Notably, compounds 6 derived from Ser, and 7 derived from Lys exhibited remarkable effects on the A549 and U373. The IC50 values for these compounds were determined to be 0.001 and 0.007 mM, respectively. These findings indicate a significantly higher potency of compounds 6 and 7 than the other tested compounds. Among the tested compounds, only compound 5 displayed significant cytotoxic activity against the Vero cell line.

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27/09/2024 01:56:53 p. m.